Why use invertebrates?

“N2MO provides cutting-edge ex vivo insect based screening models for predicting ADMET properties of chemical substances in the early drug discovery phase. Insect models represents excellent model systems due to biological active test situation, combined with fast reproducibility with no need for resynthesizing compound and at same time the model produces data that are reflecting mammalian ADMET properties”

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Insects are useful as substitutes to vertebrate models for a number of reasons:

  • Similar basic pharmacology – Prototypical CNS drugs induce similar responses
  • Insect brain barrier functionality has been highly conserved during evolution
  • Insect brain barrier contain tight junctions  – Similar diffusional barrier functionality
  • Efflux transporters expressed in brain barrier – Similar active barrier functionality
  • Full pharmacokinetic profiling can be performed in larger insect species
  • Potential for full PKPD models in individual animals
  • Insects contain all elements of mammalian absorption, distribution, metabolism and excretion.
  • Contains fully functional plasma/brain compartments which reflect the overall mammalian morphology more realistically than isolated in vitro assays.
  • Less ethical concerns than for higher order species
  • No need for resynthesizing test compound – Test is performed on ready-made stock solutions (100ul of 10mM DMSO stock solution)

Feedback from the principal DMPK scientist at Lundbeck

“The grasshopper model show high potential as an alternative to rodent and in vitro tools to assess compounds brain exposure and may be a useful tool to screen for CNS drugs in drug discovery.”

N2MO Optimizes Your Drug Discovery