“N2MO provides cutting-edge ex vivo insect based screening models for predicting ADMET properties of chemical substances in the early drug discovery phase. Insect models represents excellent model systems due to biological active test situation, combined with fast reproducibility with no need for resynthesizing compound and at same time the model produces data that are reflecting mammalian ADMET properties”
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Insects are useful as substitutes to vertebrate models for a number of reasons:
Similar basic pharmacology – Prototypical CNS drugs induce similar responses
Insect brain barrier functionality has been highly conserved during evolution