Lundbeck presented data at the 4th International Conference Clinically Relevant Drug Transporters, 22 – 23 2013 in Berlin
Recent data obtained by using our optimized model was presented by Lundbeck in Berlin at the 4th International Conference Clinically Relevant Drug Transporters – 22 – 23 April, 2013.
In summary the data shows:
- that our ex vivo grasshopper model performed well compared to existing in vitro and in vivo approaches to assess brain penetration of compounds
- importantly the model did not suffer from false under-prediction of permeability – a problem seen with in vitro models
- the data also highlights the importance of taking in vivo measurements at equilibrium and at the right concentrations – variables that are readily controlled in the ex vivo grasshopper model